Per2 has time on its side.
نویسنده
چکیده
منابع مشابه
Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death
Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. Circadian disruptions have been implicated in the onset and progression of various cancers, including those arising in the breast. Several links between the circadian protein Per2 and DNA damage responses exi...
متن کاملCircadian behavior of mice deficient in PER1/PML or PER2/PML
BACKGROUND Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML's contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1-/-/Pml-/- and Per2-/-/Pml-/- genotypes. RESULTS Her...
متن کاملProtein phosphatase 1 regulates the stability of the circadian protein PER2.
The circadian clock is regulated by a transcription/translation negative feedback loop. A key negative regulator of circadian rhythm in mammals is the PER2 (mammalian PERIOD 2) protein. Its daily degradation at the end of the night accompanies de-repression of transcription. CKI (casein kinase I ) has been identified as the kinase that phosphorylates PER2, targeting it for ubiquitin-mediated pr...
متن کاملDiurnal Expression of the Per2 Gene and Protein in the Lateral Habenular Nucleus
The suprachiasmatic nucleus plays an important role in generating circadian rhythms in mammals. The lateral habenular nucleus (LHb) is closely linked to this structure. Interestingly, the LHb shows a rhythmic firing rate in vivo and in vitro, and sustained oscillation of rhythmic genes in vitro. However, under the in vivo condition, whether rhythmic gene expression in the LHb has circadian rhyt...
متن کاملResearch progress on the central mechanism underlying regulation of visceral biological rhythm by per2 (Review).
The period circadian clock 2 (per2) gene plays an important role in modulating the circadian rhythm in the central nervous system. Its protein product, PER2, is mainly expressed in the suprachiasmatic nucleus (SCN) and limbic system, including the central nucleus of the amygdala (CeA), the bed nucleus of the stria terminalis (BNST) and the hippocampus. PER2 rhythmic expression regulates hypotha...
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ورودعنوان ژورنال:
- Nature chemical biology
دوره 3 3 شماره
صفحات -
تاریخ انتشار 2007